Udayavni Special

COVID-19: 3 Ind-Americans showing signs of recovery after transfused with plasma from recovered patients


PTI, Apr 13, 2020, 8:16 AM IST

Houston: Three Indian Americans, who were hospitalized in a critical condition for COVID-19 here, are showing signs of recovery after being transfused with plasma from recovered COVID-19 patients, hospital sources have said.

As the vaccine for COVID-19 is not expected for months and new cases are increasing daily, doctors in Texas and around the country are experimenting with a new treatment based on an old technique, but aren’t sure if it to be fully effective.

The treatment injects antibody-rich plasma from people who have recovered from the novel coronavirus into people who have severe cases of COVID-19, the disease caused by the virus. Antibodies are proteins in blood that fight specific bacteria and viruses.

In the absence of a vaccine, doctors and scientists are looking to convalescent plasma because they consider it low risk and because it has been effective during past epidemics.

Five patients at Baylor St. Luke’s Medical Center in Houston part of the Baylor College of Medicine have been treated with convalescent plasma, said Dr. Ashok Balasubramanyam, vice president of academic integration and associate dean of academic affairs at the Baylor College of Medicine.

The school has also been authorized to conduct a clinical trial, expected to start within a couple of weeks.

Three Indian American COVID-19 patients IT professional Rohan Bavadekar, Dr. Lavanga Veluswamy and Sushm Singh, are being treated at St Luke’s Medical Center in Houston, and have found recently recovered donors with same blood groups for plasma transfusion.

According to hospital sources, they are showing positive signs of recovery and waiting for more donors for new rounds of plasma transfusion.

“Vaccines for broad use would take about 12-18 months, and we don’t have time to wait,” said Lola Adepoju, a health services researcher at the University of Houston College of Medicine.

“While those vaccines are being developed, what can we do? (Convalescent plasma) therapy definitely is one of those things we can actually pursue, said the researcher,” she said.

The Food and Drug Administration is yet to approve the treatment but is allowing initial clinical trials. Because those trials are limited, doctors nationally can also request for the FDA’s permission to use the treatment for severe COVID-19 cases.

Last week, the FDA tapped the Mayo Clinic to lead and coordinate the effort and evaluate the treatment’s effectiveness.

Since then, hospital systems around the nation have registered through the Mayo Clinic to start treating patients with convalescent plasma.

On Thursday, a patient in Austin received a convalescent plasma infusion, the first in the city, said Dr. Jeff Yorio, a hematologist and oncologist at Texas Oncology who helped get the programme started in Austin.

“Of course we all want to be very hopeful about a treatment like this, Yorio said. But at the same time, we don’t truly know how effective it’s going to be compared to other types of things we’re already doing.

Yorio said that the programme has identified at least five other Austin patients with severe or life-threatening cases of COVID-19 whom doctors want to treat with plasma. The FDA has approved patients within hours of receiving a request, he added.

“We’re identifying the absolute sickest patients first, Yorio said. If we’re able to get more plasma out there that’s available, then maybe we’d be able to expand that further to other patients.

The plasma came from Austin’s blood bank, We Are Blood, which has connected with more than 20 potential plasma donors who have recovered from COVID-19 and that number should grow as word about the program gets out, said Nick Canedo, a spokesman for We Are Blood.

“Donors for convalescent plasma must have received a lab-confirmed positive test for the coronavirus or test positive for COVID-19 antibodies after recovery and be symptom-free for at least 28 days before donating,” Canedo said, adding that many potential donors have been unable to get tested for the coronavirus because their symptoms were not severe enough to qualify for one.

“Someone who initially tests positive and then has a second test for the coronavirus that comes back negative can donate after being symptom-free for 14 days,” Canedo said.

Plasma recipients must be of the same blood type group as the donor.

“This is not the first time physicians have used plasma to combat infectious diseases before a vaccine is developed. The technique was used to treat hemorrhagic fever in 1979 and the Spanish influenza in 1918,” Adepoju said, and it helped reduce mortality in both epidemics.

But when convalescent plasma was used to treat Ebola in 2014 in Guinea, Sierra Leone and Liberia, research didn’t find it to be effective.

With the FDA’s blessing, doctors have also been trying to treat COVID-19 patients with hydroxychloroquine, a drug typically used to treat malaria and lupus that has shown in limited research potential to speed recovery.

“But it comes with risks: Administered in high doses, the drug can cause heart arrhythmia and cardiac arrest,” said Dr. Kristin Mondy, chief of the division of infectious disease at the University of Texas at Austin’s Dell Medical School.

“Hydroxychloroquine has bigger safety concerns than convalescent plasma,” Mondy said.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Navy finds some debris of crashed MiG-29K in Arabian sea

Serum Institute rejects charges levelled by vaccine trial participant, threatens to seek damages

K’taka COVID-19 update: 1291 new cases, 1530 recoveries, 15 deaths on Nov 28

India ‘pharmacy of world,’ focusing on deeper ties in S&T: Swedish amb

PM hailing farm laws shows govt ‘drunk with power’, ‘rigid’ in face of protests: Cong

UP registers first case under anti-conversion law in Bareilly

Modi’s Hyd visit: A testimony of Telangana achievement, KCR should have been invited, says KTR



Related Articles More

Pope, with new cardinals, warns church against mediocrity

Pandemic calls off Christmas markets in Europe

Barack Obama approves Drake to play him in a potential biopic

Ex-Trump campaign aide sues over Russia probe surveillance

Continuing Chinese construction activities along Indian border ‘provocative measure’: US lawmaker

MUST WATCH

Meet the man with the largest collections of Newspapers | Umesh Rao Ekkar Mangalore

Mangalore: Woman rescues a cat from 30 feet deep well | Ranjini Shetty | Udayavani

CM and central leadership will take final call on Cabinet expansion: Ashwath Narayan

Assorted flowers, fruits, and vegetables are grown in the terrace garden

Celebrating 25 Years of Laveena Masala | Since 1996 | Udayavani

Latest Additions

Navy finds some debris of crashed MiG-29K in Arabian sea

Serum Institute rejects charges levelled by vaccine trial participant, threatens to seek damages

Will Hold Punjab CM Responsible if Farmers’ Gatherings Aggravate Covid in Haryana, Says Khattar

High Octane Campaign for Hyderabad Polls Ends; 67 Lakh Voters to Decide Fate of 1,222 Candidates on Dec 1

K’taka COVID-19 update: 1291 new cases, 1530 recoveries, 15 deaths on Nov 28

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.