Covid infection may induce severe bone loss, animal study suggests
PTI, May 28, 2022, 11:00 AM IST
Image Source: National Herald
Infection with the SARS-CoV-2 virus, which causes COVID-19, can lead to severe bone loss during the acute and post-recovery phases of the disease, according to a study conducted in hamsters.
The findings, recently published in the peer-reviewed journal Nature Communications, provide insights into the possible long-term complications of COVID-19.
In addition to lung infection, complications of different organ systems in the long-term SARS-CoV-2 infection, or “long COVID,” have been increasingly recognised in patients with disease, the researchers said.
However, the full spectrum of clinical manifestations, especially the influence of SARS-CoV-2 infection on bone metabolism, has yet to be fully understood, they said.
To study the effects of SARS-CoV-2 infection on bone metabolism, the researchers from the University of Hong Kong (HKUMed) infected Syrian hamsters with SARS-CoV-2.
They then collected their bone tissues after the infection and analysed them using three-dimensional microcomputerised tomography (CT) scans.
The study found that SARS-CoV-2 infection induced severe bone loss from 20 per cent to 50 per cent progressively in particular to the trabecular bone in the long bones and lumbar vertebrae.
This effect extended from the acute phase to the chronic phase of infection, according to the researchers.
The pathological osteopenia — loss of minerals like calcium and phosphate by bones — was found to be associated with the inflammatory activation of osteoclasts — a kind of cell responsible for break down of the bone tissue.
The cytokine dysregulation or inability to control inflammation, induced by SARS-CoV-2, triggered an amplified pro-inflammatory cascade in the skeletal tissues to augment their breakdown.
The researchers said their team is the first in the world to report the effects of SARS-CoV-2 on bone metabolism using a well-established Syrian hamster model that closely mimics COVID-19 in humans.
The findings indicate that the pathological bone loss may be an important but neglected complication, which warrants more extensive investigations during the long-term follow-up of COVID-19 patients, they added.
Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.
Top News
Related Articles More
Surgical options for Parkinson’s disease
Breast cancer to cause a million deaths a year by 2040: Lancet commission
Will to resist temptations, achieve goals more trustworthy than using apps, study finds
Govt directs e-commerce firms to remove drinks, beverages from ‘health drinks’ category
Experiencing abuse, neglect as child linked to lifelong ill-health: Study
MUST WATCH
Latest Additions
India’s boundaries are completely secure: Rajnath Singh
Complaint filed against Flipkart, BigBasket for allegedly making employee work on election day
DKShi ‘kidnapped’ 9-year-old girl for property: HDD
Woman can’t be held accountable for abetting suicide of lover due to ‘love failure’: Delhi HC
I don’t believe in star power: Vidhu Vinod Chopra on why content matters more to him