Over 60 new genetic regions behind stroke identified, may lead to new therapies


PTI, Oct 5, 2022, 2:13 PM IST

New Delhi: An international team, including researchers from India, have identified 61 new genetic regions associated with stroke that are potential drug targets to prevent or treat the second leading cause of death worldwide.

Previous genome studies on stroke were conducted predominantly in populations of European ancestry.

The latest results, recently published in the journal Nature, are based on the analysis of data from 2.5 million people from five different ancestries, more than 200,000 of whom had a stroke.

Members of the GIGASTROKE consortium, including Professor Kameshwar Prasad, former head of the department of Neurology at All India Institute of Medical Sciences (AIIMS), Delhi, conducted the research.

“The population studied in this research has a fairly global representation including South Asia, which includes India and Pakistan, Africa, East Asia, Europe and Latin America,” Prasad, who is currently the director of Rajendra Institute of Medical Sciences, Ranchi, told PTI.

“The combined results from different ancestries and regions made things clearer at a micro level,” he added.

In 110,182 patients who have had a stroke and 1,503,898 control individuals, the team identified association signals for stroke and its subtypes at 89 (61 new) independent gene loci.

Loci are the physical locations of genes on chromosomes in cells and have been called genetic street addresses.

A follow-up in 89,084 additional cases of stroke and 1,013,843 control individuals, 87 per cent of the primary stroke risk regions and 60 per cent of the secondary stroke risk region were replicated.

The study also highlighted F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 regions as possible targets, with drugs already under investigation for stroke for F11 and PROC regions.

Prasad and his team contributed data of 4,088 individuals — 1,609 stroke cases and 2,479 controls — from the South Asia, which included India and Pakistan.

They found that the frequency of a genetic region called COBL is higher in people suffering neurological disorders from India and Pakistan. Higher frequency of this region was not identified in patients from other ancestries.

“Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries,” Prasad noted.

Stroke is the second leading cause of death worldwide, responsible for approximately 12 per cent of total deaths, with an increasing burden particularly in low-income countries.

Characterised by a neurological deficit of sudden onset, stroke is predominantly caused by cerebral ischaemia, a common mechanism of acute brain injury that results from impaired blood flow to the brain.

The frequency of stroke subtypes differs between ancestry groups as exemplified by a higher prevalence of small-vessel stroke (SVS) and intracerebral haemorrhage (ICH) in Asian and African populations compared with European populations.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Bengaluru: 3 JMB operatives sentenced to 7-year imprisonment in two terror-related cases

22-year old woman raped by bike taxi driver and his friend in Bengaluru

Number of Christians falls as Muslims, Hindus rise in England

Kishkinda: Banners, poster on banning non-Hindu traders displayed at Anjanadri Hills removed

Former Bengal minister Manab Mukherjee dies

UNDP official Usha Rao-Monari to visit India

Sooda: Annual feast held at Sooda Sri Subramanya Swamy Temple


Related Articles More

Skyroot Aerospace plans to launch Vikram-1 in one year

Govt exempts ISRO from provisions of explosives rule

India’s SARAS telescope gives clues to first stars, galaxies of universe

AgniKul Cosmos sets up India’s first private launchpad at Sriharikota spaceport

China to launch three astronauts for its space station; unveils plans for manned Moon mission

MUST WATCH

Deepotsava at Shri Durga Adishakti temple

Girija Surgicals nebulizer vedio

KL Rahul Visit Kukke Subrahmanya Temple

Police commissioner N.Shahsikumar statement about viral video

CCTV Footage about mangaluru incident


Latest Additions

Bengaluru: 3 JMB operatives sentenced to 7-year imprisonment in two terror-related cases

22-year old woman raped by bike taxi driver and his friend in Bengaluru

Number of Christians falls as Muslims, Hindus rise in England

Kishkinda: Banners, poster on banning non-Hindu traders displayed at Anjanadri Hills removed

Gujarat polls: BJP’s attack on Patkar attempt to paint Congress against state’s interests

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.