UK scientists trial instant immunity antibody drug treatment for COVID-19

Team Udayavani, Dec 26, 2020, 5:04 PM IST

Credit: AP photo


London: Scientists in the UK have begun trials of innovative antibody drug treatments that they hope could provide instant protection against COVID-19.

The University College London Hospitals NHS Trust (UCLH) said that the researchers in the Storm Chase study believe a Long Acting AntiBody (LAAB) known as AZD7442, developed by AstraZeneca, may offer immediate and long-term protection to people who have been recently exposed to the SARS-CoV-2 coronavirus and prevent them developing COVID-19.

The study, led by UCLH virologist Dr Catherine Houlihan, recruited the first participant in the world to the study earlier this month and has recruited 10 participants since then.

“We know that this antibody combination can neutralise the virus, so we hope to find that giving this treatment via injection can lead to immediate protection against the development of COVID-19 in people who have been exposed – when it would be too late to offer a vaccine,” said Houlihan.

UCLH said its new vaccine research centre is running two clinical trials testing a LAAB combination treatment to protect against COVID-19.

The second Provent study is looking at the use of AZD7442 in people who may not respond to vaccination, for instance where someone has a compromised immune system or are at increased risk of COVID-19 infection due to factors such as age and existing conditions.

“We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine.

“We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective,” said Dr Nicky Longley, UCLH infectious diseases consultant leading the Provent study.

Antibodies are protein molecules that the body produces to help fight infections. Monoclonal antibodies are artificially produced in a laboratory and designed as possible medical treatments. They are designed to be injected directly into the body, unlike vaccines which “train” the immune system itself to produce antibodies.

“These two clinical trials are an important addition to testing new therapeutic approaches, as antibody treatments may offer an alternative to patient groups who cannot benefit from a vaccine, such as immunocompromised patients,” said Professor Stephen Powis, the medical director of National Health Service (NHS) England.

The LAABs have been engineered with AstraZeneca’s “proprietary” half-life extension technology to increase the durability of the therapy for six to 12 months following a single administration. The combination of two LAABs is also designed to reduce the risk of resistance developed by the SARS-CoV-2 virus, which causes COVID-19.

“AZD7442 has the potential to be an important preventative and therapeutic medicine against COVID-19, focusing on the most vulnerable patients. This work complements our vaccine development programme,” said Mene Pangalos, AztraZeneca Executive Vice-President for BioPharmaceuticals Research and Development.

“Storm Chaser is exploring the use of a combination of monoclonal antibodies given intramuscularly in those who have been exposed to SARS-CoV-2 – a setting where vaccination would not have time to work and we have no other proven therapies to date. This makes Storm Chaser an important study that may have a large impact on our ability to control this infection,” noted Professor Andrew Ustianowski, who is the chief investigator of the new studies.

UCLH said that in both Provent and Storm Chaser, researchers will assess whether the treatment reduces the risk of developing COVID-19 and/or reduces the severity of infection compared to placebo.

Key participant groups in the Storm Chaser trial will include healthcare workers, students who live in group accommodation, and patients who are exposed to anyone with the SARS-CoV-2 virus as well as residents of long-term care facilities and industrial/military settings.

Both trials are taking place at the newly-created Vaccine Research Centre at UCLH, which opened this month to help accelerate the development of new vaccines and treatments during the COVID-19 pandemic.

“Both Storm Chaser and Provent are crucial to finding a solution to this pandemic,” said Professor Vincenzo Libri, who leads the UCLH Clinical Research Facility backed by the UK’s National Institute for Health Research (NIHR).

“The opening of our new Vaccine Research Centre will help to propel our fight against the virus, meet our aspiration to save as many lives as possible, and ensure a return to normality,” he said.

“The recent progress on vaccines is hugely welcome, and developing these additional treatments will be vital to ensure everyone in society can be offered protection against COVID-19,” Professor Marcel Levi, UCLH Chief Executive, said.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Unnao rape survivor moves SC, seeks transfer of ‘counter case’ from UP to Delhi

Didn’t let China intrude into India’s territory: Rajnath

BCI raps Prashant Bhushan, says no one has authority to ridicule SC, its judges and judiciary

Hassan: Divorce case – Man slits wife’s throat in court premises

Madikeri: Man stabs college students at tourist spot; love affair suspected

Congress need not teach patriotism to RSS: Union Minister Karandlaje

Narcotics worth Rs 111.41 crore seized at Chennai airport, foreigner among 2 held

Related Articles More

Cornea implant from pig skin used to restore sight in Indian patients

Indian researchers use fish ear bones to estimate seawater temperature

The world’s biggest ice sheet is more vulnerable to global warming than scientists previously thought

New test can tell how much immunity you have against COVID-19

Policybazaar system vulnerabilities exposed customers’ personal details: Report


| KABBINALE | Mysterious Waterfall Of Hebri

Shri Araga Gyanendra addressed the gathering. |udayavaninews

News bulletin 13-8-2022

How to cultivate a forest concept

Mother Rescued her son from snake

Latest Additions

Unnao rape survivor moves SC, seeks transfer of ‘counter case’ from UP to Delhi

Didn’t let China intrude into India’s territory: Rajnath

Meat at temple: Police arrest main accused

BCI raps Prashant Bhushan, says no one has authority to ridicule SC, its judges and judiciary

Sri Lanka allows docking of Chinese research ship at Hambantota port from Aug 16-22

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.