Widely used e-cigarette flavouring impairs lung function


Team Udayavani, May 28, 2018, 5:16 PM IST

Washington: A common e-cigarette flavouring has toxic chemicals similar to those found in tobacco smoke, which disrupts the lungs’ antibacterial defence system, a study has found.

“Our data suggest that when used in e-cigarettes cinnamaldehyde, like toxic aldehydes in cigarette smoke, significantly disrupts normal cell physiology in ways that may have implications for the development and exacerbation of the respiratory disease,” said Phillip Clapp, at the University of North Carolina in the US.

“Our finding that cinnamaldehyde impairs normal airway cilia motility is significant because it demonstrates that a common, food-safe flavouring agent, in the context of e-cigarette use, is capable of dysregulating a critical anti-bacterial defence system in the lungs,” said Clapp.

Cinnamaldehyde is the chemical that gives cinnamon its characteristic flavour and odour.

Researchers performed their experiment by exposing human bronchial epithelial cell (HBEC) cultures to diluted cinnamon e-liquids and e-liquid aerosols from a third generation e-cigarette device.

The frequency of movement of hair-like projections (cilia) that clear mucus and dirt from the lungs – that is, cilia beat frequency (CBF) – was measured over 120 minutes using a high-speed digital camera and a video analysis system.

The cinnamaldehyde content of each e-liquid was determined, and HBECs were then exposed to various concentrations of cinnamaldehyde to determine if cilia beat frequency changed as the dose increased.

The researchers evaluated changes in mitochondria oxidation phosphorylation, the process by which cells generate the majority of their cellular energy.

Several different reactive aldehydes, a group of chemicals also found in cigarette smoke, cause lung inflammation, and increase susceptibility to bacterial and viral infections.

In recent years, e-cigarettes have emerged as potentially safer alternatives to traditional cigarettes because they provide the sensation of smoking and the desired nicotine effect without burning tobacco.

“E-cigarette emissions contain chemicals that have not been evaluated for inhalation toxicities. The inhalation of flavouring agents, which are frequently reactive aldehydes, poses a significant unknown in regards to the potential health risks of e-cigarette use as many of these chemicals are structurally similar to toxic aldehydes in cigarette smoke,” said Clapp.

“Moreover, aldehyde flavouring agents are often used in exceedingly high concentrations in e-cigarettes, which may lead to high exposure doses,” he added.

Researchers decided to conduct this experiment because many food additives “generally recognised as safe (GRAS)” by the US Food and Drug Administration (FDA) have been added to e-cigarettes without further study of their effects when inhaled.

They became especially concerned after looking at the chemical structures of various e-cigarette flavouring agents that have chemical structures similar to those that are found in cigarette smoke with known toxicities.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

WCD Ministry invites suggestions on draft amendments to juvenile justice rules

Woman in the United States is addicted to eating walls

Centre extends nationwide Covid containment measures till November 30

Aryan Khan granted bail by Bombay High Court in Mumbai cruise drugs case

Elephants fight over lorry load of sugarcane, stop traffic on Dindigul-Bengaluru highway

BJP won’t go anywhere for next many decades, says Prashant Kishor; takes swipe at Rahul Gandhi

Mangaluru: 11 boats used in illegal sand mining seized

Related Articles More

Wild Himalayan fig may be used as natural pain reliever, animal study finds

Your unvaccinated friend is roughly 20 times more likely to give you COVID

Mild to moderate cases in home isolation can infect only one-third contacts: WHO-MAMC study

Two patients with serious issues stemming from obesity undergo surgery using robot-assisted tool

Ivermectin: Misuse against COVID risks undermining its use for other diseases

MUST WATCH

Basavaraj Bommai at Hubballi

Geetagayana at Kaup Beach

Karnataka rajyotsava celebrations: Mass rendition of Kannada songs at Udupi DC Office

Tiger swimming in kabini back water at mysore

Alerts for tourists visiting the Ettina Bujja


Latest Additions

Centre must forthwith notify norms of teacher-pupil ratio for special schools: SC

WCD Ministry invites suggestions on draft amendments to juvenile justice rules

Sensex crashes 1159 pts to end day below 60k, Nifty down by 354 pts

Woman in the United States is addicted to eating walls

BJP will be wiped out in UP in next year’s Assembly polls: Akhilesh

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.