Udayavni Special

Breast cancer drugs may help treat resistant lung cancers

Team Udayavani, Dec 27, 2018, 1:30 PM IST

London: A class of drugs used to treat certain breast cancers could help fight lung cancers that have become resistant to targeted therapies, according to a study conducted in mice.

The study, published in the journal Cell Reports, found that lung tumours in mice caused by mutations in a gene called EGFR shrunk significantly when a protein called p110 was blocked.

Drugs to block p110 are currently showing promise in clinical trials against certain breast cancers, so could be approved for clinical use in the near future, said researchers from the Francis Crick Institute and the Institute of Cancer Research (ICR) in the UK.

The new findings suggest that these drugs could potentially benefit patients with EGFR-mutant lung cancers whose tumours have become resistant to treatment.

“At the moment, patients with EGFR-mutant lung cancers are given targeted treatments that are very effective for the first few years,” said Professor Julian Downward, who has labs at the Francis Crick Institute and the ICR.

“These drugs are improving, but unfortunately after a couple of years the cancer usually becomes resistant and starts to grow and spread again,” Julian said.

The second line of treatment is currently conventional chemotherapy, which is not targeted and has substantial side-effects, researchers said.

It would be worth investigating whether p110 inhibitors could be used as a second-line therapy, they said. The team targeted a specific interaction between the RAS protein and p110. The RAS gene is mutated in around one in five cancers, causing uncontrolled growth, and is a key focus of the study.

When the researchers blocked this interaction in genetically modified mice with EGFR mutations, their tumours shrank significantly. Before the intervention, the tumours filled around two thirds of the space inside the lung.

When the interaction between RAS and p110 was genetically blocked, this shrank significantly to about a tenth of the space inside the lung. The intervention also had very few side-effects.

“As we wanted to pinpoint the specific interaction responsible, we used a genetic technique that would not be practical in a patient treatment,” said Julian.

“We’re looking to develop ways to do this with drugs, as blocking this specific pathway would significantly reduce side-effects, but this work is many years from the clinic,” Julian said.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

I beg govt to make arrangements for last rites of COVID victims in dignified manner: HDK

Health ministry advises proning position in self care for Covid-19 patients

Oxygen will last 2 hours; 25 Covid-19 patients have died in last 24 hrs at Delhi’s Sir Ganga Ram Hospital

Covid-19: Canada bans flights from India and Pakistan for 30 days

Govt issues revised clinical guidance for management of COVID-19 patients

Demand for medical oxygen increases in twin districts

13 COVID-19 patients die in Maha hospital fire

Related Articles More

Health ministry advises proning position in self care for Covid-19 patients

How long does protection from COVID-19 vaccines last?

Do not fall prey to these myths surrounding COVID-19

What is double masking? Does it give better protection?

Know why is it important to check the label of the packaged food before consuming


Shocking animal cruelty in M’luru: Dog tied to bike with rope, dragged

H D Kumaraswamy slams Karnataka govt

News Bulletin 22 -4- 2021

Udayavani Phone-in program related to the development of Markets in Mangaluru


Latest Additions

Ola to launch e-scooter in July, to set up 1 lakh charging points in 400 cities

IOC approves Tchaikovsky music as Russian anthem at Olympics

I beg govt to make arrangements for last rites of COVID victims in dignified manner: HDK

‘Avoid all travel’: US issues advisory against India as Covid-19 surge

Twitter goes crazy after seeing Kaviya Maran smile during SRH vs PBKS clash

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.