‘Effective tuberculosis vaccine in the offing’


Team Udayavani, Nov 27, 2017, 4:50 PM IST

London: Scientists have taken an important step forward in their quest to develop an effective vaccine against tuberculosis – the world’s deadliest infectious disease. Tuberculosis (TB) kills more people than any other infection, with an estimated 1.7 million people worldwide die from it every year, researchers said.

The airborne disease is becoming increasingly resistant to antibiotics, but despite 20 years of intense global efforts no effective vaccine has been developed, they said. Recent efforts have focused on the response of conventional human T cells – a type of white blood cell essential to fighting off infection – to protein fragments found in Mycobacterium tuberculosis (Mtb), the bacteria that causes TB.

Now, researchers from the universities of Southampton and Bangor in the UK, have shown that certain lipids – fatty substances essential to cell structure that is found in abundance in Mtb – could trigger an immune response from other, ‘unconventional’ types of T cells. In the study published in the journal PNAS, the team showed that a group of lipids called mycolic acids – a major component of the Mtb cellular envelope – could be key to determining an immune response.

The study showed that the geometry, chemical make-up and movement of the mycolic acids’ long lipid ‘tails’ when they are embedded in a type of human protein called CD1b determines the response of the body’s unconventional T cells.

“This is an exciting discovery with potential therapeutic implications for TB patients. We have shown that synthetic lipids related to those in the cell wall of Mtb are selectively targeted by T-cells,” said Salah Mansour, from the University of Southampton. “Our findings could help drive advances in vaccine development through the intelligent design of the lipid components of future TB vaccines,” said Mansour.

“This is a very exciting result of a collaboration between organic chemists and immunologists which could provide a real opportunity for improved protection against TB,” Juma’a Al Dulayymi, from Bangor University added.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Gender pay gap deepens during COVID, women left behind on pay hike, bonuses: Study

Mustering process for MLC election begins in DK-Udupi constituency; DCs visit centres to oversee preparations

Farmers call off agitation; to vacate Delhi borders on December 11

VicKat wedding telecast rights sold to Amazon Prime for a whopping Rs 80 crore

Karnataka No 1 in India for first dose vaccination coverage: Sudhakar

Chopper crash: Sole survivor Captain Varun Singh likely to be shifted to Bengaluru for treatment

DoT to deactivate extra SIM of subscribers beyond 9 connections


Related Articles More

Natural infection and vaccination provide maximum protection against Covid variants: Study

Time of day affects immune response to Covid vaccination: Study

Vaccine makers racing to update COVID shots, just in case

Alcohol deaths up almost 19% during pandemic – greatest increase since 2001

Can Prozac treat COVID? Perhaps, but a related drug may be better

MUST WATCH

MANGALORE THEFT CASE

Untimely rains spell trouble for paddy harvest, farmers use machine instead

Udayavani news Bulletin – 8-12-2021

Karnataka : A Success Story of Karamballi Couple in Jasmine Cultivation Udayavani

Cow Eats Gold Chain at Sirsi


Latest Additions

Pak actress booked for making obscene videos of fellow artists: FIA

Gender pay gap deepens during COVID, women left behind on pay hike, bonuses: Study

Biden to decry democracy ‘recession’ at White House summit

Technology woes: Stokes’ overstepping exposes Ashes problem

Mangaluru: Two arrested for serial temple thefts; Rs 28.40 lakh worth valuables seized

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.