Indian-American-led clinical trial of ‘remdesivir’ in COVID-19 treatment shows positive results


PTI, Apr 30, 2020, 7:52 AM IST

Washington: The phase three clinical trial of the antiviral drug remdesivir, led by a team of investigators including an Indian-American physician, for the treatment of the coronavirus patients has shown positive results, an American pharma company announced on Wednesday.

The California-based pharma company Gilead Sciences said that the preliminary results showed that 50 percent of the COVID-19 patients treated with a 5-day dosage of remdesivir improved and more than half were discharged from the hospital within two weeks. A phase three clinical trial is said to be the final step in the process of drug approval.

“Certainly, it’s a positive it’s a very positive event,” Trump told reporters in response to a question on the latest result of the clinical trial of remdesivir.

The White House described the development as “quite good news”. The pharma company also said that it is also aware of positive data emerging from the National Institute of Allergy and Infectious Diseases’ (NIAID) study of the investigational antiviral remdesivir for the treatment of the COVID-19.

“We understand that the trial has met its primary endpoint and that NIAID will provide detailed information at an upcoming briefing,” it said.

Remdesivir is not yet licensed or approved anywhere globally and has not been demonstrated to be safe or effective for the treatment of the COVID-19.

The study sought to determine whether a shorter, five-day course of remdesivir would achieve similar efficacy results as the 10-day treatment regimen used in multiple ongoing studies of remdesivir, the company said.

“These data are encouraging as they indicate that patients who received a shorter, 5-day course of remdesivir experienced similar clinical improvement as patients who received a 10-day treatment course,” said Aruna Subramanian, MD, Clinical Professor of Medicine, Chief, Immunocompromised Host Infectious Diseases, Stanford University School of Medicine, and one of the lead investigators of the study.

“While additional data are still needed, these results help to bring a clearer understanding of how treatment with remdesivir may be optimized, if proven safe and effective,” Subramanian said.

The company said it will share additional remdesivir data from the company’s open-label Phase three SIMPLE trial in patients with severe COVID-19 disease shortly.

Dr. Anthony Fauci, a key member of the White House coronavirus task force, told reporters at a media briefing with Trump that Gilead results from the remdesivir clinical trial for treating the disease showed “quite good news”.

“So that’s something that will go with 31 percent improvement, doesn’t seem like a knockout, 100 percent, it is a very important proof of concept,” Fauci said.

“This is very optimistic, the mortality rate trended towards being better in the sense of less deaths in the REM designate group. Eight percent versus 11 percent in the placebo group. So bottom line. You’re going to hear more details about this will be submitted to a peer reviewed journal, and will be peer reviewed appropriately,” said Fauci.

In an earlier interview to Stanford Medicine, Subramanian said that during normal times, a phase three clinical trial typically takes months of planning, after years of research before it is underway.

“But these aren’t normal times. With a fast-moving pandemic bearing down and no approved treatments available, researchers are, like everyone else, desperate for answers, and they have ramped up their efforts to find solutions. Remdesivir jumped to the top of the list of potential treatments in part because it was farthest along in the approval process,” Subramanian said.

By the end of February, as the virus spread in the United States, there were at least five clinical trials of remdesivir underway.

China initiated the first two studies in February, followed later that month by the Gilead trials for severe and moderate patients and the NIH trial. By the end of March, Gilead had expanded to 100 testing sites both in the United States and abroad, and the NIH trial had expanded to 60 sites, 50 of those in the United States, Stanford Medicine reported.

A coronavirus infection occurs when the germ enters the body’s airways through the nose, mouth or eyes, then lodges in the cells in the lining of the lung’s airways, where it quickly starts to make millions of copies of itself, wreaking havoc on the lungs, Subramanian told the Medical publication.

The virus makes copies of itself by inserting its own genes into the human cell’s genetic machinery, basically hijacking the replication process of the human cell.

“Remdesivir, like other anti-virals, is designed to target the system the virus uses to replicate, acting as a cap that prevents the virus from making new copies of itself or infecting other cells,” she said.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Active COVID-19 cases dip to 17,317

BSY’s son Vijayendra prefers to wait till BJP decides his name as MLC candidate

‘Gaali Gopura to be built atop Anjanadri hill’

Ullal: Woman’s suspicious death turns out to be murder

All-round RR humble LSG by 24 runs, inch closer to play-offs

My visit to Nepal intended to further deepen ‘time-honoured’ linkages: PM Modi

Titans tame CSK to secure top-two finish


Related Articles More

Active COVID-19 cases dip to 17,317

North Korea reports 8 deaths as Kim laments virus response

Karnataka records 126 new COVID-19 cases, zero fatalities

Facemasks can reduce Covid severity, pressure on health systems, study confirms

China trade weakens after cities shut down to fight virus

MUST WATCH

NEWS BULLETIN 15-05-2022

CT Ravi Statement about Congress

Thousands Witness Ancient Tulunadu Celebration of ‘Pilikola’

NEWS BULLETIN 14-05-2022

Cow Steeling at Kumta : CCTV Footage Found


Latest Additions

Djokovic shows he’s back in top form with Italian Open title

WATCH: Dramatic video shows small plane crash on bridge near Miami, striking an SUV

‘Once Upon a Time in Calcutta’, ‘Shoebox’, ‘Taangh/Longing’ hog top awards at 2022 NYIFF

How diamond baron Dholakia got Rs 920 for first trade!

Stem cell therapy offers a new hope to repair brain damage in newborns

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.