Latest study in mice paves way for developing universal flu vaccine

PTI, Nov 25, 2022, 1:52 PM IST

Representational Image

Washington: Scientists have developed an mRNA lipid nanoparticle vaccine containing antigens from all twenty known subtypes of influenza A and B viruses, a strategy which may serve as the basis for universal flu vaccines, according to a study.

The vaccine, developed by researchers from the US and Canada, produced high levels of cross-reactive and subtype-specific antibodies in mice and ferrets and could protect animals against disease symptoms and death after infection with both antigenically matched and mismatched strains of influenza, the study said.

According to the study, even with increased global surveillance, it is difficult to predict which flu strain will cause the next flu pandemic, making a universal vaccine important.

The approach by the scientists differed from previous attempts to craft a universal flu vaccine by including antigens specific to each subtype, rather than just a smaller set of antigens shared among subtypes, the study published in the journal Science said.

Following the success of mRNA vaccines against SARS-CoV-2, the researchers prepared 20 different nanoparticles encapsulated mRNAs, each encoding a different hemagglutinin antigen – a highly immunogenic flu protein that helps the virus enter cells, the study said.

Antibody levels remained mostly stable four months after vaccination in the mice, the study said.

Multivalent protein vaccines produced using more traditional methods elicited fewer antibodies and were less protective compared to the multivalent mRNA vaccine in the animals, said the study.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

K’taka discusses investment plans with Foxconn chairman

All-out efforts to save VISL will be taken: CM Bommai tells workers

I wear 140 cr Indians’ trust as protective shield, lies can’t breach it: PM Modi hits back at Oppn

Celebrate ‘Cow Hug Day’ on Feb 14: Animal Welfare Board of India

10 Indians stuck in remote areas of quake-hit Turkiye, but safe: MEA

Temple priest confronts Kumaraswamy over his “anti Brahmin” remarks

Farmers need to link bank account with Aadhaar by Feb 10 for getting benefits under PM Kisan

Related Articles More

More than one in two cancer patients experience long Covid symptoms: Study

Why we should not reuse plastic water bottles

Stunning interior design trends for 2023

Mental health consulting needs to be included in health insurance: Report

WHO calls for strengthening health systems for prevention, early detection of cancer


solutions for urination a problem

Pangala Crime News

A successful coastal farmer growing watermelons

Mahesh Joshi Interview

Success Story of Mr bean

Latest Additions

Hope fading as deaths in Turkiye, Syria quake pass 11,000

K’taka discusses investment plans with Foxconn chairman

NGT slaps Noida-based realtor with Rs 113.25 cr fine, raps ED for delayed action

All-out efforts to save VISL will be taken: CM Bommai tells workers

France’s Total puts hydrogen partnership with Adani on hold pending clarity on allegation

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.